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M9490474.TXT
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1994-09-19
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Document 0474
DOCN M9490474
TI Successful bone marrow transplantation in a boy with X-linked
lymphoproliferative syndrome and acute severe infectious mononucleosis.
DT 9411
AU Pracher E; Panzer-Grumayer ER; Zoubek A; Peters C; Gadner H; St. Anna
Children's Hospital, Vienna, Austria.
SO Bone Marrow Transplant. 1994 May;13(5):655-8. Unique Identifier :
AIDSLINE MED/94332079
AB We report a 5.9-year-old boy with X-linked lymphoproliferative syndrome
(XLP) who presented with acute severe infectious mononucleosis. Clinical
symptoms rapidly improved after chemotherapy with etoposide. Allogeneic
bone marrow transplantation (BMT) was performed after conditioning with
etoposide, busulfan and cyclophosphamide. After successful hematopoietic
recovery we were able to demonstrate seroconversion from an impaired
antibody response to Epstein-Barr virus (EBV) to a normal
antibody-producing state in an immunocompetent child. The only
post-transplant complication was mild acute graft-versus-host disease
(GVHD). Three years after BMT, the boy is healthy and shows no signs of
immunodeficiency. This is the first report on successful allogeneic BMT
in the severe course of acute infectious mononucleosis in a patient with
XLP. We speculate that the application of etoposide contributed to the
positive outcome in this patient.
DE Acute Disease *Bone Marrow Transplantation Case Report Child,
Preschool Etoposide/THERAPEUTIC USE Human Infectious
Mononucleosis/*THERAPY *Linkage (Genetics) Lymphoproliferative
Disorders/GENETICS/*THERAPY Male Transplantation, Homologous *X
Chromosome JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).